Immunoglobulin E and Indigenous Susceptibility to Infectious Diseases

Description

Many authors have written about the social and economic risk factors such as poverty, low educational attainment, and discrimination that contribute to global indigenous-nonindigenous disparity. In this work, we consider an additional immunological risk factor — T-helper 2 dominance —

Many authors have written about the social and economic risk factors such as poverty, low educational attainment, and discrimination that contribute to global indigenous-nonindigenous disparity. In this work, we consider an additional immunological risk factor — T-helper 2 dominance — that appears to exacerbate the effects of social and economic factors on infectious disease outcomes in tropical zones. To this end, a critical review approach was used to extract published data on total serum IgE — an indicator of T-helper 2 dominance. We found a three-orders-of-magnitude differences in total serum IgE across climate zones (tropical vs. temperate), ecologies within the tropics (forests vs. urban/rural), and clinical conditions (HIGE, TPE, ABAP vs. atopy, and helminthiasis). Additionally, that the highest ever reported total serum IgE levels are reported for tropical regions - mainly, healthy members of forest-dwelling indigenous groups of South America, and patients diagnosed with clinical conditions such as onchocerciasis, tropical pulmonary eosinophilia, and hyper-IgE.

Date Created
2022-05
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