Within the scope of Humanitarian Assistance and Disaster Relief (HADR), this thesis reviews some major challenges during mass evacuations, illustrated by incidents during actual mass evacuation scenarios, and identifies several potential applications of autonomous unmanned aerial vehicles (UAVs) in the effort to ease the transition of evacuees out of a disaster area. System requirements and example UAV platforms are identified for applications in which autonomous UAVs monitor traffic conditions along evacuation routes, distribute information to the public, and establish a communications network for first responders.