SRC Dependent EGFRvIII-STAT5 Activation Drives Resistance of Glioblastoma Cells
Description
Glioblastoma (GBM) is the most lethal primary brain tumor in adults with a less than 5% chance of survival beyond 5 years. With few effective therapies beyond the standard of care, there are often treatment resistant recurrences seen in most patients. STAT5 is a protein that has shown to be upregulated in highly invasive and treatment resistant GBM. Elucidating the role of STAT5 in GBM could reveal a node of therapeutic vulnerability in primary and recurrent GBM.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2022-05
Agent
- Author (aut): Inforzato, Hannah
- Thesis director: Plaisier, Christopher
- Committee member: Tran, Nhan
- Committee member: Blomquist, Mylan
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): School of Life Sciences
- Contributor (ctb): Department of Psychology