Native American COVID vaccination trends have deviated from the vaccinated trends for other vaccines such as the HPV and flu. Native Americans are reporting the highest vaccinations in the nation compared to all racial and ethnic groups in the country. Despite this, some are still hesitant in taking the vaccine. This study investigates the factors that influence vaccine uptake and hesitancy among Native American Youth in Arizona. The study utilizes data from the Arizona Youth Identity Project, a mixed-methods study examining young adults’ political engagement and sense of identity as Americans. 10 out of 13 individuals at the time of the study had received the COVID vaccine. Three themes, trust, knowledge, and social responsibility were identified. Most of the reasons for hesitancy came from distrust of government and biomedicine. Most participants had no knowledge of vaccine effectiveness, mechanism or effects but viewed getting vaccinated as a social responsibility to protect their families and communities. These findings indicate that the main goal of vaccinations among Native American youth was to protect the most vulnerable elders.