Deep brain stimulation (DBS) is a neurosurgical procedure involving placement of an electrode in the form of a DBS lead into a deep brain nucleus to treat a variety of neurologic conditions such as Parkinson’s Disease and Essential Tremor. DBS lead placement requires a head-mounted stereotactic device that utilizes a three-dimensional coordinate system to locate a surgical target. Traditional stereotactic systems are designed for a wide variety of procedures and therefore can be large and cumbersome, causing patient discomfort. To address this, NaviNetics, Inc. has recently developed the FDA 510(k)-cleared D1 Stereotactic system. This system replaces the conventional base frame to a 44.45 mm X 44.45 mm skull-anchored platform called the Key. The Key serves as the interface to which other components of the D1 Stereotactic system, including imaging localizers and the D1 Frame, easily attach and detach from the patient’s head without disrupting stereotactic spatial reference. We have now advanced the system to an aluminum design that has demonstrated a mechanical accuracy of ≤ 0.9mm. This manuscript outlines a step-by-step protocol for using the D1 Stereotactic system to aid in DBS surgery. Link to video.