Investigating Biocompatibility of 3D Multiferroic and Piezoelectric Scaffolds for Tissue Regeneration Treatment

Bone tissue diseases involve the weakening of bones' flexibility, often leading to fractures. Annually, approximately 1.5 million individuals experience this condition, with a higher prevalence observed among older age groups. The primary solutions for bone diseases include allografts, which require an available donor and have been reported to elicit potential adverse host immune responses. Consequently, there is an opportunity for innovative solutions and treatments based on bone tissue engineering. One potential treatment involves the use of piezoelectric materials to support tissue regeneration and osteogenesis. To validate the suitability of this biomaterial, this study focuses on assessing its biocompatibility, particularly regarding cell viability and adhesion. Through the use of metabolic assays and scanning electron microscopy, scaffolds composed of multi-composite and piezoelectric biomaterials have shown promise in supporting the cell types necessary for bone regeneration.