Full metadata
Title
Recognition tunneling: approaches towards next generation DNA sequencing
Description
This thesis describes several approaches to next generation DNA sequencing via tunneling current method based on a Scanning Tunneling Microscope system. In chapters 5 and 6, preliminary results have shown that DNA bases could be identified by their characteristic tunneling signals. Measurements taken in aqueous buffered solution showed that single base resolution could be achieved with economic setups. In chapter 7, it is illustrated that some ongoing measurements are indicating the sequence readout by making linear scan on a piece of short DNA oligomer. However, to overcome the difficulties of controlling DNA especially ssDNA movement, it is much better to have the tunneling measurement incorporated onto a robust nanopore device to realize sequential reading of the DNA sequence while it is being translocated.
Date Created
2011
Contributors
- Huang, Shuo (Author)
- Lindsay, Stuart (Thesis advisor)
- Sankey, Otto (Committee member)
- Tao, Nongjian (Committee member)
- Drucker, Jeff (Committee member)
- Ros, Robert (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
xvi, 133 p. : ill. (some col.)
Language
eng
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.I.8943
Statement of Responsibility
by Shuo Huang
Description Source
Retrieved Sept. 21, 2012
Level of coding
full
Note
thesis
Partial requirement for: Ph.D., Arizona State University, 2011
bibliography
Includes bibliographical references (p. 115-125)
Field of study: Physics
System Created
- 2011-08-12 03:43:19
System Modified
- 2021-08-30 01:54:51
- 3 years 2 months ago
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