Full metadata
Title
The Production of a Chimeric Monoclonal Antibody as a Therapeutic Agent Against Flaviviruses
Description
A chimeric, humanized monoclonal antibody that recognizes a highly conserved fusion loop found on flaviviruses was constructed with a geminiviral replicon and transiently expressed in Nicotiana benthamiana plants through Agrobacterium tumefaciens infiltration. Characterization and expression studies were then conducted to confirm correct assembly of the antibody. Once the antibody was purified, an ELISA was conducted to validate that the antibody was able to bind to the flavivirus fusion loop.
Date Created
2018-05
Contributors
- Pardhe, Mary (Author)
- Mason, Hugh (Thesis director)
- Chen, Qiang (Committee member)
- Mor, Tsafrir (Committee member)
- School of Life Sciences (Contributor)
- Department of Information Systems (Contributor)
- W.P. Carey School of Business (Contributor)
- Barrett, The Honors College (Contributor)
Topical Subject
Resource Type
Extent
23 pages
Language
eng
Copyright Statement
In Copyright
Primary Member of
Series
Academic Year 2017-2018
Handle
https://hdl.handle.net/2286/R.I.47905
Level of coding
minimal
Cataloging Standards
System Created
- 2018-04-19 12:11:01
System Modified
- 2021-08-11 04:09:57
- 3 years 2 months ago
Additional Formats