133792-Thumbnail Image.png
Description
A chimeric, humanized monoclonal antibody that recognizes a highly conserved fusion loop found on flaviviruses was constructed with a geminiviral replicon and transiently expressed in Nicotiana benthamiana plants through Agrobacterium tumefaciens infiltration. Characterization and expression studies were then conducted to

A chimeric, humanized monoclonal antibody that recognizes a highly conserved fusion loop found on flaviviruses was constructed with a geminiviral replicon and transiently expressed in Nicotiana benthamiana plants through Agrobacterium tumefaciens infiltration. Characterization and expression studies were then conducted to confirm correct assembly of the antibody. Once the antibody was purified, an ELISA was conducted to validate that the antibody was able to bind to the flavivirus fusion loop.


Download restricted.
Restrictions Statement

Barrett Honors College theses and creative projects are restricted to ASU community members.

Download count: 3

Details

Title
  • The Production of a Chimeric Monoclonal Antibody as a Therapeutic Agent Against Flaviviruses
Contributors
Date Created
2018-05
Resource Type
  • Text
  • Machine-readable links