Description
A chimeric, humanized monoclonal antibody that recognizes a highly conserved fusion loop found on flaviviruses was constructed with a geminiviral replicon and transiently expressed in Nicotiana benthamiana plants through Agrobacterium tumefaciens infiltration. Characterization and expression studies were then conducted to confirm correct assembly of the antibody. Once the antibody was purified, an ELISA was conducted to validate that the antibody was able to bind to the flavivirus fusion loop.
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Details
Title
- The Production of a Chimeric Monoclonal Antibody as a Therapeutic Agent Against Flaviviruses
Contributors
- Pardhe, Mary (Author)
- Mason, Hugh (Thesis director)
- Chen, Qiang (Committee member)
- Mor, Tsafrir (Committee member)
- School of Life Sciences (Contributor)
- Department of Information Systems (Contributor)
- W.P. Carey School of Business (Contributor)
- Barrett, The Honors College (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2018-05
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