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Traditionally, hazardous chemicals have been regulated in the U.S. on a one-by-one basis, an approach that is slow, expensive and can be inefficient, as illustrated by a decades-long succession of replacing one type of organohalogen flame retardants (OHFRs) with another

Traditionally, hazardous chemicals have been regulated in the U.S. on a one-by-one basis, an approach that is slow, expensive and can be inefficient, as illustrated by a decades-long succession of replacing one type of organohalogen flame retardants (OHFRs) with another one, without addressing the root cause of toxicity and associated public health threats posed. The present article expounds on the need for efficient monitoring strategies and pragmatic steps in reducing environmental pollution and adverse human health impacts. A promising approach is to combine specific bioassays with state-of-the-art chemical screening to identify chemicals and chemical mixtures sharing specific modes of action (MOAs) and pathways of toxicity (PoTs). This approach could be used to identify and regulate hazardous chemicals as classes or compound families, featuring similar biological end-points, such as endocrine disruption and mutagenicity. Opportunities and potential obstacles of implementing this approach are discussed.

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    Title
    • Effective Strategies for Monitoring and Regulating Chemical Mixtures and Contaminants Sharing Pathways of Toxicity
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    Date Created
    2015-08-28
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.3390/ijerph120910549
    • Identifier Type
      International standard serial number
      Identifier Value
      1660-4601
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    • View the article on the journal website at http://www.mdpi.com/1660-4601/12/9/10549

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    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Venkatesan, A. K., & Halden, R. U. (2015). Effective Strategies for Monitoring and Regulating Chemical Mixtures and Contaminants Sharing Pathways of Toxicity. International journal of environmental research and public health, 12(9), 10549-10557. doi:10.3390/ijerph120910549

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