Targeting Tumors: Inclusion of Functional Groups on Ion-Containing Block Copolymers to Combat Cancer
Description
This research attempts to determine the most effective method of synthesizing a peptide such that it can be utilized as a targeting moiety for polymeric micelles. Two melanoma-associated peptides with high in vitro and in vivo binding affinity for TNF receptors have been identified and synthesized. Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-ToF) was used to help verify the structure of both peptides, which were purified using Reversed-Phase High Performance Liquid Chromatography (RP-HPLC). The next steps in the research are to attach the peptides to a micelle and determine their impact on micelle stability.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2016-05
Agent
- Author (aut): Moe, Anna Marguerite
- Thesis director: Green, Matthew
- Committee member: Jones, Anne
- Committee member: Sullivan, Millicent
- Contributor (ctb): Chemical Engineering Program
- Contributor (ctb): School of International Letters and Cultures
- Contributor (ctb): Sandra Day O'Connor College of Law
- Contributor (ctb): Barrett, The Honors College