Horatio Robinson Storer was a surgeon and anti-abortion activist in the 1800s who worked in the field of women’s reproductive health and led the Physicians’ Crusade Against Abortion in the US. Historians credit Storer as being one of the first physicians to distinguish gynecology, the study of diseases affecting women and their reproductive health, as a separate subject from obstetrics, the study of pregnancy and childbirth. Storer was one of the first physicians to successfully perform a Caesarian section, or the removal of the fetus through a surgical incision, followed by the removal of the woman’s uterus, a procedure which would later be known as Porro’s operation. Storer was also an anti-abortion activist who believed that public attitudes toward abortion were too relaxed and that the laws did not effectively punish what he deemed to be the criminal act of abortion. Historians credit Storer with leading the Physicians’ Crusade Against Abortion, which they consider largely responsible for the increase in laws criminalizing abortion in the late 1800s.

Ovarian hyperstimulation syndrome, abbreviated OHSS, is an atypical reaction that women may experience in response to excessive hormones, and often occurs during fertility treatments. OHSS is typically triggered by hormonal medications designed to mature eggs in the ovaries, which can cause blood vessels within the ovaries to leak fluid. Sometimes that can lead to painful tenderness or swelling. In severe cases of OHSS, that fluid can leak into the abdominal cavity in large amounts, causing vomiting, blood clots, and severe pain. As many as one out of three women undergoing fertility treatment will experience some form of OHSS, although more severe presentations are rare. While the exact cause of OHSS is not fully understood as of 2020, researchers continue to discover various risk factors, prevention techniques, and treatments that may lead to decreased risks associated with OHSS and better fertility outcomes.

In 2011, Cristian Persu, Christopher Chapple, Victor Cauni, Stefan Gutue, and Petrisor Geavlete published “Pelvic Organ Prolapse Quantification System (POP-Q) – A New Era in Pelvic Prolapse Staging,” in the Journal of Medicine and Life. In their article, the authors explain the need for a reliable diagnostic method for describing the state of a pelvic organ prolapse, or a condition that can result from weakness or damage to the muscles that support the pelvic organs, sometimes leading to bladder, bowel, and sexual dysfunction. Persu and colleagues describe a previous diagnostic method, the Baden-Walker Halfway Scoring System, comparing it to the newer system, the Pelvic Organ Prolapse Quantification System, referred to also as POP-Q. By examining the benefits and drawbacks of each pelvic organ prolapse measurement and diagnostic system, the authors proposed a universal acceptance of the POP-Q system, based on its accuracy and reliability.

Ian Hector Frazer studied the human immune system and vaccines in Brisbane, Australia, and helped invent and patent the scientific process and technology behind what later became the human papillomavirus, or HPV, vaccinations. According to the Centers for Disease Control and Prevention of the US, or CDC, HPV is the most common sexually transmitted infection, and can lead to genital warts, as well as cervical, head, mouth, and neck cancers. Frazer and virologist Jian Zhou conducted research in the 1990s to assess why women with HPV had higher rates of precancerous and cancerous cervical cells. Frazer’s research led the pharmaceutical company Merck to produce the Gardasil vaccination series, and GlaxoSmithKline to produce the Cervarix vaccination. Frazer’s research contributed to the development of HPV vaccinations that have been successful in reducing up to seventy percent of cervical cancer cases in women.

The HeLa cell line was the first immortal human cell line that George Otto Gey, Margaret Gey, and Mary Kucibek first isolated from Henrietta Lacks and developed at The Johns Hopkins Hospital in Baltimore, Maryland, in 1951. An immortal human cell line is a cluster of cells that continuously multiply on their own outside of the human from which they originated. Scientists use immortal human cell lines in their research to investigate how cells function in humans. Though the HeLa cell line has contributed to many advancements in biomedical research since the twentieth century, its usage in medical research has been controversial because Lacks did not consent to having her cells used for such purposes. As of 2020, scientists continue to use the HeLa cell line for numerous scientific advancements, such as the development of vaccines and the identification of many underlying disease mechanisms.

In 2009, A. John Henderson and colleagues published “Mothers’ Anxiety During Pregnancy Is Associated with Asthma in Their Children,” hereafter, “Mothers’ Anxiety,” in The Journal of Allergy and Clinical Immunology. Previous studies had shown that maternal stress during pregnancy affects children’s health during childhood. The researchers explored the association of asthma in children with maternal anxiety during pregnancy. The cause of asthma is often unknown. Thus, the researchers tested the possibility that maternal anxiety may increase disease risk in the children, particularly the development of asthma. The authors reported a positive association between maternal anxiety during pregnancy and asthma in offspring, indicating the possibility of a causal relationship. The authors’ findings demonstrated the health effects of maternal stress during pregnancy on children’s physiological and immune development.

In 2011, fetal researcher Vivette Glover published “Annual Research Review: Prenatal Stress and the Origins of Psychopathology: An Evolutionary Perspective,” hereafter, “Prenatal Stress and the Origins of Psychopathology,” in the Journal of Child Psychology and Psychiatry. In that article, Glover explained how an evolutionary perspective may be useful in understanding the effects of fetal programming. Fetal programming is a hypothesis that attempts to explain how factors during pregnancy can affect fetuses after birth. Researchers associate exposure to prenatal stress, or stress experienced before birth, with an increased likelihood of some mental disorders. Glover states that such outcomes may be traced back to a fetus’s response to stress during pregnancy, and that those outcomes may have been beneficial in the past. By taking an evolutionary approach toward understanding mental disorders, Glover provided insights for studying the lasting effects of maternal stress during pregnancy on children’s mental health.

The 1981 Adolescent Family Life Act, or AFLA, is a US federal law that provides federal funding to public and nonprofit private organizations to counsel adolescents to abstain from sex until marriage. AFLA was included under the Omnibus Reconciliation Act of 1981, which the US Congress signed into law that same year. Through the AFLA, the US Department of Health and Human Services, or HHS, funded a variety of sex education programs for adolescents to address the social and economic ramifications associated with pregnancy and childbirth among unmarried adolescents. AFLA received several criticisms for directly emphasizing and funding abstinence-only education programs from religious organizations. However, when US citizen Chan Kendrick brought the case Bowen v. Kendrick before the Supreme Court in 1988, the Court upheld that AFLA was constitutional. Although numerous evaluations have shown minimal scientific evidence supporting abstinence-only education, as of 2020, the federal government still provides funding for such programs through AFLA.

In 1971, a group of researchers founded the Monash IVF Research Program with the mission to discover how in vitro fertilization, or IVF, techniques could become a treatment for infertility in both men and women. The program included researcher Carl Wood and colleagues John Leeton, Alex Lopata, Alan Trounson, and Ian Johnston at the Queen Victoria Medical Center and Royal Women’s Hospital in Melbourne, Australia. Since the program’s establishment in 1971, the Monash IVF Research Program has helped to develop and implement many IVF technologies still used in clinical practice as of 2020. Additionally, the program established some of the first successful IVF pregnancies and births. As of 2020, the Monash IVF Research Program is one of Australia’s leading fertility programs and has used their technologies to help provide IVF treatment to thousands of infertile men and women.

Menstrupedia published the comic book Menstrupedia Comic: The Friendly Guide to Periods for Girls, hereafter Menstrupedia Comic, in July 2014 in India. Aditi Gupta, the founder of Menstrupedia and a women’s health activist, wrote Menstrupedia Comic while studying at the National Institute of Design in Gujarat, India, in 2013. Gupta worked alongside her husband, graphic designer Tuhin Paul, who provided the illustrations for the book. According to Menstrupedia, misconceptions and taboo surrounding menstruation in India prompted Gupta to develop the book. Specifically, in Hindu culture, women and girls may feel embarrassed to discuss their menstrual cycles openly, because menstruation is a process that some people consider impure. Published in eleven different languages, Menstrupedia Comic has become an educational resource for girls around the world to learn about their menstrual cycles.