The microorganisms that form the gut microbiome begin colonizing the gut at birth. The microorganisms will establish a symbiotic relationship with the host when in a state of eubiosis. However, when there is an imbalance or lack of diversity in the microorganisms present in the gut microbiome, it will shift to a state of dysbiosis, which increases the risk of inflammatory bowel and neurodegenerative diseases. There are known factors that affect the infant intestinal microbiome: mode of delivery, gestational age, and exposures, such as the use of antibiotics and feeding methods. Studies have shown that maternal lifestyle, particularly stress levels and diet, has an association with the infant microbiome diversity. However, there is limited literature that examines how postpartum maternal sleep influences the intestinal microbiome diversity in infants. We hypothesized that sleep efficiency below 85%, total sleep time and nocturnal sleep time below 7 hours, and later nocturnal sleep onset would be associated with decreased gut microbiome diversity within the sample and between samples. 27 Mother-infant pairings were used for this sub-analysis. Postpartum maternal sleep data was obtained via actigraphs and sleep diaries while infant intestinal microbiome data was obtained through fecal samples swabbed from soiled diapers. Actigraphs recorded time, movement, temperature, and light for five 24-hour periods, and sleep diaries were used to supplement the actigraphy and ease the scoring of sleep. DNA samples were extracted and sequenced using next-generation sequences, and QIIME2 was used to analyze these sequences. Alpha- and beta-diversity results following sequencing revealed good postpartum maternal sleep efficiency is associated with increased infant gut microbiome diversity within and between samples. There was a trend for nocturnal sleep onset being associated with beta-diversity measurements which were driven by phylogenetic differences and abundance of bacteria. Nocturnal total sleep time and 24-hour total sleep time were not associated with alpha- and beta-diversity. Our findings as well as the scarcity of the literature illustrate the need for further investigations on the mechanics of maternal sleep efficiency association with infant gut microbiome. Future research is needed to further evaluate the trending nocturnal sleep onset influences on the infant gut microbiome beta-diversity with a larger and more diverse sample.

Glioblastoma Multiforme is a prevalent and aggressive brain tumor. It has an average 5-year survival rate of 6% and average survival time of 14 months. Using patient-specific MRI data from the Barrow Neurological Institute, this thesis investigates the impact of parameter manipulation on reaction-diffusion models for predicting and simulating glioblastoma growth. The study aims to explore key factors influencing tumor morphology and to contribute to enhancing prediction techniques for treatment.

Memory as whole is impacted by changes associated with aging and menopause. Different memory types are often tested preclinically utilizing rats in different task paradigms. Most studies have focused on understanding social recognition or working memory, however these memory types have yet to be studied together. This thesis focuses on the process of creating and testing a new social recognition task that incorporates a working memory load. We tested different types of previously used social recognition paradigms with an increasing load and through qualitative and quantitative observations the task was modified until a final task was developed for a social working memory study. Young female rats were tested in this task in progressive, meaning a chronologically increasing load and nonprogressive, meaning non-chronological increase in load cognitions. It was found that young female rats had the ability to distinguish between the familiar and novel conspecifics before memory load exceeded four familiar and one novel conspecifics. Once validated through future studies, this task may be utilized to understand the impact of different types of menopause on social working memory.

This thesis details the importance and evidence of medieval and modern fantasy’s influence on modern video gaming. This influence is examined through the lens of three primary themes found in fantasy: magic, the bestiary, and chivalry. These themes are traced using medieval texts including The Prose Edda, The Quest for the Holy Grail, and The Death of King Arthur, modern texts including A Wizard of Earthsea, The Eye of the World, and The Way of Kings, and modern video games including The Witcher 3: Wild Hunt, God of War, and Elden Ring. The reasons why they are so prevalent and useful for developers and companies is a constant question that this thesis seeks to answer with primary attention focused on increasing gameplay length and player immersion as key strategies that allow for advanced monetization. The overall consensus of this thesis is that not only is fantasy an influential genre but that its primary themes lend themselves very well to the format of video games and that game developers and companies are using this to increase their chances of creating successful video games.

Children have been known to engage in socially curious behaviors, such as frequently asking questions about other people’s feelings and actions (Friedman et al., 2018). Social curiosity helps children engage in cultural learning and understanding the explicit and implicit rules of society (Hartung & Renner, 2013). However, little is known about how social curiosity may impact children’s moral development. Seeking out social information may help form connections between children, increasing the extent to which they behave prosocially to others. Additionally, similar constructs to social curiosity (theory of mind and empathy) are linked to prosocial behavior (Imuta et al., 2016; Ding & Lu, 2016). The present study therefore investigates the relationship between social curiosity and prosocial sharing. To test the hypothesis that children who are primed to be socially curious will exhibit increased prosocial sharing, we used the Social Uncertainty Paradigm to elicit social curiosity in children who then completed a sticker sharing task. Our hypothesis was not supported; no significant differences between the sharing behaviors of children primed for social curiosity and those who were not. Additional research is needed to conclude whether social curiosity may be linked to prosocial behavior in a way that this study was not able to determine.

A review of the experience of running a fully-remote, nationwide clinical trial centered around intermittent fasting and its effects on cognitive health in a midlife population that is living with stress, obesity, and a memory that is not as good as it used to be. As the two project managers, we had a myriad of responsibilities, which came with many challenges and successes. The preliminary results have been analyzed and the study is now in the process of manuscript development.

Burnout due to work and school-related stress negatively impacts college student’s confidence, motivation, and mindset. Burnout can manifest as lower quality of a student’s education, performance, relationships, and overall well-being. Using the Maslach Burnout Inventory™ - General Survey for Students: MBI-GS (S), researchers assessed the effectiveness of a five-part workshop series titled “A Series on Self-Reflection, Self-Understanding, and Strengthening the Mind,” focused on improving burnout symptoms in students attending ASU’s Barrett, the Honors College, against a control group of non-workshop participating honors students. Data was collected through MBI-GS (S) evaluation surveys after each workshop attendance, via the daily honors newsletter, and through subject interviews. The researchers conducted a qualitative study consistent with case studies and focus groups. Descriptive statistics of survey responses were quantified in Excel, representing varying burnout levels in honors students throughout the Spring 2023 school semester. Overall, the surveys from the workshop attendees and Honors Digest students yielded insignificant differences in burnout levels. The eight interviewee case studies emphasize the complex influences of culture and environment on burnout. While burnout levels between Honors Digest students and workshop attendees were insignificantly different, each interviewee student presented changed perspectives on their studies and themselves.

Asian Americans are facing unprecedented and growing mental health issues brought by anti-Asian Racism and other forms of hyper-visible oppression (Yellow Horse et al., 2021). In response to racism, one potential solution for bolstering mental health outcomes among Asian Americans is critical reflection. Critical reflection is the process through which oppressed and marginalized people critically analyze oppressive social conditions (e.g., racism, sexism, and more) and consider actions they can take to change them (Watts et al., 2011). Recent research suggests that, overall, there is a strong link between critical reflection and the well-being of youth of color (Maker Castro et al., 2022). However, this relationship may vary based on additional factors, such as strategies used to cope with racism-related stress. For instance, Asian Americans with lower critical reflection about racism (e.g., as evidenced by endorsement of colorblind racial ideology, or the belief that racial differences are irrelevant and racism no longer exists) had a higher tendency to use avoidant coping mechanisms to deal with discrimination (Yi et al., 2022; Lewis et al., 2019). Additionally, there is other evidence to support that Asian Americans who held more colorblind racial attitudes experienced less anxiety when challenged with ambiguous discrimination compared to Asian Americans who held less colorblind racial attitudes (Lee, 2016). Overall, the literature suggests the importance of the relationship between critical reflection and mental health. However, studies have yet to quantitatively explore the impacts of critical reflection and strategies to cope with discrimination on mental health outcomes among Asian Americans (Spanierman et al., 2021) and young adults (Maker Castro et al., 2022). The current study seeks to address this gap in the literature by examining the role of strategies to cope with discrimination in the relationship between Asian Americans’ critical reflection and mental health outcomes. It is crucial to explore these factors as Asian American students continue to shoulder prejudice, stereotypes, and systemic racism in professional and educational institutions. We hypothesize that the relationship between critical reflection and mental health will be mediated by the strategies used to cope with discrimination. More specifically, we expect that low levels of critical reflection (as indicated by high levels of color-blind racial attitudes) are related to greater use of internalization, substance use, and detachment strategies to cope with discrimination, which is related to greater endorsement of depression, anxiety, and stress symptoms. Data for this study were drawn from a larger study on college students’ experiences in ethnic studies courses. Participants were 288 Asian Americans recruited from ethnic studies courses at universities in various regions of the United States. During the first two weeks of their ethnic studies course, participants completed an online survey about their racial attitudes, critical consciousness, and psychological well-being. Mediation analyses will be conducted using the PROCESS macro (Hayes, 2022) on SPSS version 27. Critical reflection, as measured by participants’ total mean score on the Color-Blind Racial Attitudes Scale (Neville et al., 2000; Keum et al., 2018) will be included as the independent variable; subscale scores on the Coping with Discrimination Scale (Wei & Alvarez, 2010) will be mediators; and each subscale of the Depression, Anxiety, and Stress Scale (DASS-21; Henry & Crawford, 2005) will be the dependent variable in separate analyses. Relationships between the study variables and Asian subgroup (i.e., East, Southeast, and South Asian) will also be examined. While analyses are currently ongoing, preliminary findings suggest that strategies to cope with discrimination and mental health outcomes vary between East Asians, Southeast Asians, and South Asians. Additionally, preliminary findings suggest that the use of substance use and detachment to cope with discrimination explains the relationship between low critical reflection and mental health outcomes. Findings have implications for encouraging mental health specialists and educators to have open conversations about racism while helping those who experience discrimination cope in healthy ways. Thus, this research can contribute to improved psychological well-being of Asian American young adults.