Among Latinxs living in the United States (U.S.), AfroLatinx individuals are more susceptible to dying from COVID-19 because of pre-existing health conditions such as diabetes, heart disease, and hypertension (Chapman, 2020). These health disparities, in turn, have been associated with economic inequalities AfroLatinx communities face in the U.S. due to discrimination and racism (Weinstein et al., 2017). Scholars have called attention to the need to focus on AfroLatinx populations, given the systematic denial of AfroLatinx experiences in the psychological literature (Sanchez, 2021) and the systemic and institutional barriers AfroLatinx face when seeking physical and mental health support (Borrell, 2005). Using Borrell's (2005) framework for studying the determinants of health disparities affecting AfroLatinxs, in Study 1, I examined the association between individual characteristics (e.g., socioeconomic indicators), psychosocial factors (e.g., economic distress), and contextual factors (e.g., discrimination) reported by AfroLatinx adults and emotional and physical health problems during the COVID-19 pandemic. As an expansion of Borrell's model, I also examined whether having a pre-existing condition can help explain mental health distress above and beyond other determinants of health disparity. Study 2 built on the first study by helping identify the specific areas of stress and needs identified by AfroLatinxs during the COVID-19 pandemic. The second aim of Study 2 was to determine the more frequent and effective strategies AfroLatinxs with pre-existing conditions used to cope with COVID-19-related stressors and needs.