Matching Items (43,917)
Description
Hydropower generation is one of the clean renewable energies which has received great attention in the power industry. Hydropower has been the leading source of renewable energy. It provides more than 86% of all electricity generated by renewable sources worldwide. Generally, the life span of a hydropower plant is considered as 30 to 50 years. Power plants over 30 years old usually conduct a feasibility study of rehabilitation on their entire facilities including infrastructure. By age 35, the forced outage rate increases by 10 percentage points compared to the previous year. Much longer outages occur in power plants older than 20 years. Consequently, the forced outage rate increases exponentially due to these longer outages. Although these long forced outages are not frequent, their impact is immense. If reasonable timing of rehabilitation is missed, an abrupt long-term outage could occur and additional unnecessary repairs and inefficiencies would follow. On the contrary, too early replacement might cause the waste of revenue. The hydropower plants of Korea Water Resources Corporation (hereafter K-water) are utilized for this study. Twenty-four K-water generators comprise the population for quantifying the reliability of each equipment. A facility in a hydropower plant is a repairable system because most failures can be fixed without replacing the entire facility. The fault data of each power plant are collected, within which only forced outage faults are considered as raw data for reliability analyses. The mean cumulative repair functions (MCF) of each facility are determined with the failure data tables, using Nelson's graph method. The power law model, a popular model for a repairable system, can also be obtained to represent representative equipment and system availability. The criterion-based analysis of HydroAmp is used to provide more accurate reliability of each power plant. Two case studies are presented to enhance the understanding of the availability of each power plant and represent economic evaluations for modernization. Also, equipment in a hydropower plant is categorized into two groups based on their reliability for determining modernization timing and their suitable replacement periods are obtained using simulation.
Contributors
Kwon, Ogeuk (Author) / Holbert, Keith E. (Thesis advisor) / Heydt, Gerald T (Committee member) / Pan, Rong (Committee member) / Arizona State University (Publisher)
Created
2011
Description
Code-switching, a bilingual language phenomenon, which may be defined as the concurrent use of two or more languages by fluent speakers is frequently misunderstood and stigmatized. Given that the majority of the world's population is bilingual rather than monolingual, the study of code-switching provides a fundamental window into human cognition and the systematic structural outcomes of language contact. Intra-sentential code-switching is said to systematically occur, constrained by the lexicons of each respective language. In order to access information about the acceptability of certain switches, linguists often elicit grammaticality judgments from bilingual informants. In current linguistic research, grammaticality judgment tasks are often scrutinized on account of the lack of stability of responses to individual sentences. Although this claim is largely motivated by research on monolingual strings under a variety of variable conditions, the stability of code-switched grammaticality judgment data given by bilingual informants has yet to be systematically investigated. By comparing grammaticality judgment data from 3 groups of German-English bilinguals, Group A (N=50), Group B (N=34), and Group C (N=40), this thesis investigates the stability of grammaticality judgments in code-switching over time, as well as a potential difference in judgments between judgment data for spoken and written code-switching stimuli. Using a web-based survey, informants were asked to give ratings of each code-switched token. The results were computed and findings from a correlated groups t test attest to the stability of code-switched judgment data over time with a p value of .271 and to the validity of the methodologies currently in place. Furthermore, results from the study also indicated that no statistically significant difference was found between spoken and written judgment data as computed with an independent groups t test resulting in a p value of .186, contributing a valuable fact to the body of data collection practices in research in bilingualism. Results from this study indicate that there are significant differences attributable to language dominance for specific token types, which were calculated using an ANOVA test. However, when using group composite scores of all tokens, the ANOVA measure returned a non-significant score of .234, suggesting that bilinguals with differing language dominances rank in a similar manner. The findings from this study hope to help clarify current practices in code-switching research.
Contributors
Grabowski, Jane (Author) / Gilfillan, Daniel (Thesis advisor) / Macswan, Jeff (Thesis advisor) / Ghanem, Carla (Committee member) / Arizona State University (Publisher)
Created
2011
Description
Systemic lupus erytematosus (SLE) is an autoimmune disease where the immune system is reactive to self antigens resulting in manifestations like glomerulonephritis and arthritis. The immune system also affects the central nervous system (known as CNS-SLE) leading to neuropsychiatric manifestations such as depression, cognitive impairment, psychosis and seizures. A subset of pathogenic brain-reactive autoantibodies (BRAA) is hypothesized to bind to integral membrane brain proteins, affecting their function, leading to CNS-SLE. I have tested this BRAA hypothesis, using our lupus-mouse model the MRL/lpr mice, and have found it to be a reasonable explanation for some of the manifestations of CNS-SLE. Even when the MRL/lpr had a reduced autoimmune phenotype, their low BRAA sera levels correlated with CNS involvement. The correlation existed between BRAA levels to integral membrane protein and depressive-like behavior. These results were the first to show a correlation between behavioral changes and BRAA levels from brain membrane antigen as oppose to cultured neuronal cells. More accurate means of predicting and diagnosing lupus and CNS-SLE is necessary. Using microarray technology I was able to determine peptide sets that could be predictive and diagnostic of lupus and each specific CNS manifestation. To knowledge no test currently exists that can effectively diagnose lupus and distinguish between each CNS manifestations. Using the peptide sets, I was able to determine possible natural protein biomarkers for each set as well as for five monoclonal BRAA from one MRL/lpr. These biomarkers can provide specific targets for therapy depending on the manifestation. It was necessary to investigate how these BRAA enter the brain. I hypothesized that substance P plays a role in altering the blood-brain barrier (BBB) allowing these BRAA to enter and affect brain function, when bound to its neurokinin-1 receptor (NK-1R). Western blotting results revealed an increase in the levels of NK-1R in the brain of the MRL/lpr compared to the MRL/mp. These MRL/lpr with increased levels of both NK-1R and BRAA displayed CNS dysfunction. Together, these results demonstrate that NK-1R may play a role in CNS manifestations. Overall, the research conducted here, add to the role that BRAA are playing in CNS-lupus.
Contributors
Williams, Stephanie (Author) / Hoffman, Steven A (Thesis advisor) / Conrad, Cheryl (Committee member) / Chen, Julian (Committee member) / Orchinik, Miles (Committee member) / Arizona State University (Publisher)
Created
2011
Description
Frederic Thrasher's early work with youth gangs in Chicago continues to influence contemporary gang research. Thrasher's basic premise, that conflict with outside groups facilitates strong interpersonal ties between adolescents, has yet to undergo quantitative analysis. Using data from Wave II of the National Longitudinal Study of Adolescent Health ("Add Health"), this conflict is measured by the aggregate number of juvenile arrests for property and violent crimes in a community. Multivariate regression is conducted to explore the impact of police threat on number of friendship nominations, while logistic regression is conducted to see if police threat is impacting relationship strength between respondent's first male and female friend. The results from both the multivariate and logistic regressions do not support Thrasher's hypothesis. Implications for future research are discussed.
Contributors
Moule, Richard K (Author) / Katz, Charles M. (Thesis advisor) / Ready, Justin T. (Committee member) / Pratt, Travis C. (Committee member) / Arizona State University (Publisher)
Created
2011
Description
Let T be a tournament with edges colored with any number of colors. A rainbow triangle is a 3-colored 3-cycle. A monochromatic sink of T is a vertex which can be reached along a monochromatic path by every other vertex of T. In 1982, Sands, Sauer, and Woodrow asked if T has no rainbow triangles, then does T have a monochromatic sink? I answer yes in the following five scenarios: when all 4-cycles are monochromatic, all 4-semi-cycles are near-monochromatic, all 5-semi-cycles are near-monochromatic, all back-paths of an ordering of the vertices are vertex disjoint, and for any vertex in an ordering of the vertices, its back edges are all colored the same. I provide conjectures related to these results that ask if the result is also true for larger cycles and semi-cycles. A ruling class is a set of vertices in T so that every other vertex of T can reach a vertex of the ruling class along a monochromatic path. Every tournament contains a ruling class, although the ruling class may have a trivial size of the order of T. Sands, Sauer, and Woodrow asked (again in 1982) about the minimum size of ruling classes in T. In particular, in a 3-colored tournament, must there be a ruling class of size 3? I answer yes when it is required that all 2-colored cycles have an edge xy so that y has a monochromatic path to x. I conjecture that there is a ruling class of size 3 if there are no rainbow triangles in T. Finally, I present the new topic of alpha-step-chromatic sinks along with related results. I show that for certain values of alpha, a tournament is not guaranteed to have an alpha-step-chromatic sink. In fact, similar to the previous results in this thesis, alpha-step-chromatic sinks can only be demonstrated when additional restrictions are put on the coloring of the tournament's edges, such as excluding rainbow triangles. However, when proving the existence of alpha-step-chromatic sinks, it is only necessary to exclude special types of rainbow triangles.
Contributors
Bland, Adam K (Author) / Kierstead, Henry A (Thesis advisor) / Czygrinow, Andrzej M (Committee member) / Hurlbert, Glenn H. (Committee member) / Barcelo, Helene (Committee member) / Aen, Arunabha (Committee member) / Arizona State University (Publisher)
Created
2011
Description
The San Andreas Fault (SAF) is the primary structure within a system of faults accommodating motion between the North American and Pacific plates. Physical models of faulting and characterizations of seismic hazard are informed by investigations of paleoseismology, slip distribution, and slip rate. The impact of earthquakes on people is due in large part to social vulnerability. This dissertation contributes an analysis about the relationships between earthquake hazard and social vulnerability in Los Angeles, CA and investigations of paleoseismology and fault scarp array complexity on the central SAF. Analysis of fault scarp array geometry and morphology using 0.5 m digital elevation models along 122 km of the central SAF reveals significant variation in the complexity of SAF structure. Scarp trace complexity is measured by scarp separation, changes in strike, fault trace gaps, and scarp length per SAF kilometer. Geometrical complexity in fault scarp arrays indicates that the central SAF can be grouped into seven segments. Segment boundaries are controlled by interactions with subsidiary faults. Investigation of an offset channel at Parkfield, CA yields a late Holocene slip rate of 26.2 +6.4/- 4.3 mm/yr. This rate is lower than geologic measurements on the Carrizo section of the SAF and rates implied by far-field geodesy. However, it is consistent with historical observations of slip at Parkfield. Paleoseismology at Parkfield indicates that large earthquakes are absent from the stratigraphic record for at least a millennia. Together these observations imply that the amount of plate boundary slip accommodated by the main SAF varies along strike. Contrary to most environmental justice analyses showing that vulnerable populations are spatially-tied to environmental hazards, geospatial analyses relating social vulnerability and earthquake hazard in southern California show that these groups are not disproportionately exposed to the areas of greatest hazard. Instead, park and green space is linked to earthquake hazard through fault zone regulation. In Los Angeles, a parks poor city, the distribution of social vulnerability is strongly tied to a lack of park space. Thus, people with access to financial and political resources strive to live in neighborhoods with parks, even in the face of forewarned risk.
Contributors
Toké, Nathan A (Author) / Arrowsmith, J R (Thesis advisor) / Boone, Christopher G (Committee member) / Heimsath, Arjun M (Committee member) / Shock, Everett L (Committee member) / Whipple, Kelin X (Committee member) / Arizona State University (Publisher)
Created
2011
Description
The objective of this project was to evaluate human factors based cognitive aids on endoscope reprocessing. The project stems from recent failures in reprocessing (cleaning) endoscopes, contributing to the spread of harmful bacterial and viral agents between patients. Three themes were found to represent a majority of problems: 1) lack of visibility (parts and tools were difficult to identify), 2) high memory demands, and 3) insufficient user feedback. In an effort to improve completion rate and eliminate error, cognitive aids were designed utilizing human factors principles that would replace existing manufacturer visual aids. Then, a usability test was conducted, which compared the endoscope reprocessing performance of novices using the standard manufacturer-provided visual aids and the new cognitive aids. Participants successfully completed 87.1% of the reprocessing procedure in the experimental condition with the use of the cognitive aids, compared to 46.3% in the control condition using only existing support materials. Twenty-five of sixty subtasks showed significant improvement in completion rates. When given a cognitive aid designed with human factors principles, participants were able to more successfully complete the reprocessing task. This resulted in an endoscope that was more likely to be safe for patient use.
Contributors
Jolly, Jonathan D (Author) / Branaghan, Russell J (Thesis advisor) / Cooke, Nancy J. (Committee member) / Sanchez, Christopher (Committee member) / Arizona State University (Publisher)
Created
2011
Description
Cancer diseases are among the leading cause of death in the United States. Advanced cancer diseases are characterized by genetic defects resulting in uncontrollable cell growth. Currently, chemotherapeutics are one of the mainstream treatments administered to cancer patients but are less effective if administered in the later stages of metastasis, and can result in unwanted side effects and broad toxicities. Therefore, current efforts have explored gene therapy as an alternative strategy to correct the genetic defects associated with cancer diseases, by administering genes which encode for proteins that result in cell death. While the use of viral vectors shows high level expression of the delivered transgene, the potential for insertion mutagenesis and activation of immune responses raise concern in clinical applications. Non-viral vectors, including cationic lipids and polymers, have been explored as potentially safer alternatives to viral delivery systems. These systems are advantageous for transgene delivery due to ease of synthesis, scale up, versatility, and in some cases due to their biodegradability and biocompatibility. However, low efficacies for transgene expression and high cytotoxicities limit the practical use of these polymers. In this work, a small library of twenty-one cationic polymers was synthesized following a ring opening polymerization of diglycidyl ethers (epoxides) by polyamines. The polymers were screened in parallel and transfection efficacies of individual polymers were compared to those of polyethylenimine (PEI), a current standard for polymer-mediated transgene delivery. Seven lead polymers that demonstrated higher transgene expression efficacies than PEI in pancreatic and prostate cancer cells lines were identified from the screening. A second related effort involved the generation of polymer-antibody conjugates in order to facilitate targeting of delivered plasmid DNA selectively to cancer cells. Future work with the novel lead polymers and polymer-antibody conjugates developed in this research will involve an investigation into the delivery of transgenes encoding for apoptosis-inducing proteins both in vitro and in vivo.
Contributors
Vu, Lucas (Author) / Rege, Kaushal (Thesis advisor) / Nielsen, David (Committee member) / Sierks, Michael (Committee member) / Arizona State University (Publisher)
Created
2011
Description
Phase contrast magnetic resonance angiography (PCMRA) is a non-invasive imaging modality that is capable of producing quantitative vascular flow velocity information. The encoding of velocity information can significantly increase the imaging acquisition and reconstruction durations associated with this technique. The purpose of this work is to provide mechanisms for reducing the scan time of a 3D phase contrast exam, so that hemodynamic velocity data may be acquired robustly and with a high sensitivity. The methods developed in this work focus on the reduction of scan duration and reconstruction computation of a neurovascular PCMRA exam. The reductions in scan duration are made through a combination of advances in imaging and velocity encoding methods. The imaging improvements are explored using rapid 3D imaging techniques such as spiral projection imaging (SPI), Fermat looped orthogonally encoded trajectories (FLORET), stack of spirals and stack of cones trajectories. Scan durations are also shortened through the use and development of a novel parallel imaging technique called Pretty Easy Parallel Imaging (PEPI). Improvements in the computational efficiency of PEPI and in general MRI reconstruction are made in the area of sample density estimation and correction of 3D trajectories. A new method of velocity encoding is demonstrated to provide more efficient signal to noise ratio (SNR) gains than current state of the art methods. The proposed velocity encoding achieves improved SNR through the use of high gradient moments and by resolving phase aliasing through the use measurement geometry and non-linear constraints.
Contributors
Zwart, Nicholas R (Author) / Frakes, David H (Thesis advisor) / Pipe, James G (Thesis advisor) / Bennett, Kevin M (Committee member) / Debbins, Josef P (Committee member) / Towe, Bruce (Committee member) / Arizona State University (Publisher)
Created
2011
Description
This dissertation creates models of past potential vegetation in the Southern Levant during most of the Holocene, from the beginnings of farming through the rise of urbanized civilization (12 to 2.5 ka BP). The time scale encompasses the rise and collapse of the earliest agrarian civilizations in this region. The archaeological record suggests that increases in social complexity were linked to climatic episodes (e.g., favorable climatic conditions coincide with intervals of prosperity or marked social development such as the Neolithic Revolution ca. 11.5 ka BP, the Secondary Products Revolution ca. 6 ka BP, and the Middle Bronze Age ca. 4 ka BP). The opposite can be said about periods of climatic deterioration, when settled villages were abandoned as the inhabitants returned to nomadic or semi nomadic lifestyles (e.g., abandonment of the largest Neolithic farming towns after 8 ka BP and collapse of Bronze Age towns and cities after 3.5 ka BP during the Late Bronze Age). This study develops chronologically refined models of past vegetation from 12 to 2.5 ka BP, at 500 year intervals, using GIS, remote sensing and statistical modeling tools (MAXENT) that derive from species distribution modeling. Plants are sensitive to alterations in their environment and respond accordingly. Because of this, they are valuable indicators of landscape change. An extensive database of historical and field gathered observations was created. Using this database as well as environmental variables that include temperature and precipitation surfaces for the whole study period (also at 500 year intervals), the potential vegetation of the region was modeled. Through this means, a continuous chronology of potential vegetation of the Southern Levantwas built. The produced paleo-vegetation models generally agree with the proxy records. They indicate a gradual decline of forests and expansion of steppe and desert throughout the Holocene, interrupted briefly during the Mid Holocene (ca. 4 ka BP, Middle Bronze Age). They also suggest that during the Early Holocene, forest areas were extensive, spreading into the Northern Negev. The two remaining forested areas in the Northern and Southern Plateau Region in Jordan were also connected during this time. The models also show general agreement with the major cultural developments, with forested areas either expanding or remaining stable during prosperous periods (e.g., Pre Pottery Neolithic and Middle Bronze Age), and significantly contracting during moments of instability (e.g., Late Bronze Age).
Contributors
Soto-Berelov, Mariela (Author) / Fall, Patricia L. (Thesis advisor) / Myint, Soe (Committee member) / Turner, Billie L (Committee member) / Falconer, Steven (Committee member) / Arizona State University (Publisher)
Created
2011