Effects of Corn Flour Consumption on Cardiovascular Disease in Adults with High Cholesterol

The prevalence of cardiovascular diseases, closely associated with elevated cholesterol levels, remains a significant public health concern worldwide. Dietary interventions, particularly the consumption of whole grains, have been advocated for their potential in reducing cholesterol levels and mitigating cardiovascular risk. However, the specific impact of corn flour, a staple in many diets, on cholesterol modulation remains underexplored. This thesis aims to address this gap by exploring how three varieties of corn flour (refined, whole grain, and excellent fiber mixture) provided by the North American Millers Association Corn Division (NAMA) affect both LDL cholesterol levels and triglycerides. This study was conducted using a randomized-single blinded crossover design. There were three treatment periods that were each 4-weeks long, each treatment period consisting of a different flour treatment. There was a 2-week washout period in between each treatment making the study a total of 16 weeks. During each treatment period, blood samples were collected from each participant to analyze LDL and triglyceride levels. At the beginning and end of each treatment period, two blood samples were taken to account for day-to-day variability. Pre-intervention LDL cholesterol levels were compared to post-intervention LDL cholesterol levels using a general linear model. This study found that LDL cholesterol levels were significantly reduced by the excellent fiber mixture by ~10 mg/dL. Whole grains and refined grains, however, had no significant effect on LDL cholesterol levels. None of the corn flour treatments had a significant effect on triglyceride levels. The overall results of the study indicated that implementing the excellent fiber mixture into the diet could be effective in reducing risk for cardiovascular disease.