Full metadata
Title
The Impact of FOXM1 Knockout on FGF1 and CHIR99021-Induced Cell Proliferation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Description
As the need for whole heart transplantation to treat heart failure grows faster than the supply,
alternative methods are in increasing demand. Transplantation of cardiomyocytes to replace
injured myocardium after MI has shown promise. Myocardium is notoriously ineffective at
proliferating after switching from hyperplastic to hypertrophic growth. FOXM1 has been
established as having a strong role in cell cycle regulation in cancerous tumors and
cardiomyocytes, and these experiments show the relationship between FOXM1 and
iPSC-derived cardiomyocyte proliferation and attempt to improve a treatment option for heart
failure through manipulation of this gene. Our experiment concludes that FOXM1 knockdown
increases iPSC-CM cell proliferation, and can be further explored to better increase
cardiomyocyte proliferation.
Date Created
2024-05
Contributors
- Hatfield, Jax (Author)
- Kresin, Zachary (Co-author)
- Weaver, Jessica (Thesis director)
- Tang, Ling (Committee member)
- Barrett, The Honors College (Contributor)
- School of Life Sciences (Contributor)
- Chemical Engineering Program (Contributor)
Topical Subject
Resource Type
Extent
23 pages
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Series
Academic Year 2023-2024
Handle
https://hdl.handle.net/2286/R.2.N.192403
System Created
- 2024-04-11 08:07:57
System Modified
- 2024-05-14 04:33:32
- 5 months 3 weeks ago
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