Description
As the need for whole heart transplantation to treat heart failure grows faster than the supply,
alternative methods are in increasing demand. Transplantation of cardiomyocytes to replace
injured myocardium after MI has shown promise. Myocardium is notoriously ineffective at
proliferating after switching from hyperplastic to hypertrophic growth. FOXM1 has been
established as having a strong role in cell cycle regulation in cancerous tumors and
cardiomyocytes, and these experiments show the relationship between FOXM1 and
iPSC-derived cardiomyocyte proliferation and attempt to improve a treatment option for heart
failure through manipulation of this gene. Our experiment concludes that FOXM1 knockout
increases iPSC-CM cell proliferation, and can be further explored to better increase
cardiomyocyte proliferation.
Details
Title
- The Impact of FOXM1 Knockout on FGF1 and CHIR99021-Induced Cell Proliferation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Contributors
- Kresin, Zachary (Author)
- Hatfield, Jax (Co-author)
- Weaver, Jessica (Thesis director)
- Tang, Ling (Committee member)
- Barrett, The Honors College (Contributor)
- Harrington Bioengineering Program (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2024-05
Resource Type
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