Full metadata
Title
Utilizing Self-lysis Salmonella as a Vaccine Delivery System to Target Cancer Tumor cells
and Induce Apoptosis and Immune Response: A Focus on the Construction of the Suicide Vector
Description
Modified Salmonella strains and recombinant DNA in a plasmid are used to construct a
Salmonella strain that is dependent on the experimentally inserted plasmid. This construction
will be done via lab techniques such as polymerase chain reactions (PCR), transformation, and other means to create this construction. With future successful construction, the inhibition of flagella assembly, within the tumor environment, and increased synthesis of flagellin will be
possible. In the case that only assembly is prevented, then, the reliance on the lysis system to
release flagellin into the tumor microenvironment will be used as a means to induce immune
response. With the success of the self-lysis ability, these strains could be used to target these
tumor cells to deliver anticancer material as a vaccine delivery system.
Date Created
2024-05
Contributors
- Shagi, Agnel (Author)
- Kong, Wei (Thesis director)
- Fu, Lingchen (Committee member)
- Barrett, The Honors College (Contributor)
- School of Life Sciences (Contributor)
Topical Subject
Resource Type
Extent
16 pages
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Series
Academic Year 2023-2024
Handle
https://hdl.handle.net/2286/R.2.N.192320
System Created
- 2024-04-11 11:37:47
System Modified
- 2024-04-22 03:52:38
- 6 months 3 weeks ago
Additional Formats