Full metadata
Title
Towards Very Early Interrogation of Neurodegenerative Diseases with Diffusion MRI
Description
It is hypothesized that changes in brain tissue microstructure, particularly degradation of neurites (i.e,. axons and dendrites) and synapses, are early drivers of Alzheimer's disease (AD) pathogenesis. Quantitative magnetic resonance imaging (MRI) tools like diffusion tensor imaging (DTI) have long been used to study AD pathogenesis. Using DTI metrics, structural insights of neuro tissue can be inferred but not directly measured. DTI has proven to be an effective tool indicating fractional anisotrophy (FA) differences between groups of varying AD risk factor, but it does not explicitly quantify pathophysiologically-relevant features like neurite density and complexity. This study aims to develop and validate an advanced diffusion MRI acquisition and biophysical modeling platform that can be used to explicitly quantify changes to brain tissue microstructure, specifically neurite density and complexity. Ultimately, this platform will be used to study the pathogenic mechanisms that drive AD in the pre-clinical and clinical setting.
Date Created
2023
Contributors
- Yamada, Nelson Garr (Author)
- Beeman, Scott (Thesis advisor)
- Schaefer, Sydney (Committee member)
- Su, Yi (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
33 pages
Language
eng
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.2.N.190840
Level of coding
minimal
Cataloging Standards
Note
Partial requirement for: M.S., Arizona State University, 2023
Field of study: Biomedical Engineering
System Created
- 2023-12-14 01:33:36
System Modified
- 2023-12-14 01:33:41
- 11 months 1 week ago
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