Description
Alzheimer's disease (AD) is a neurodegenerative disease that damages the cognitive abilities of a patient. It is critical to diagnose AD early to begin treatment as soon as possible which can be done through biomarkers. One such biomarker is the beta-amyloid (Aβ) peptide which can be quantified using the centiloid (CL) scale. For identifying the Aβ biomarker, A deep learning model that can model AD progression by predicting the CL value for brain magnetic resonance images (MRIs) is proposed. Brain MRI images can be obtained through the Alzheimer's Disease Neuroimaging Initiative (ADNI) and Open Access Series of Imaging Studies (OASIS) datasets, however a single model cannot perform well on both datasets at once. Thus, A regularization-based continuous learning framework to perform domain adaptation on the previous model is also proposed which captures the latent information about the relationship between Aβ and AD progression within both datasets.
Details
Title
- A Continuous Learning Approach to Alzheimer’s Disease Progression Modeling and Domain Adaptation among Imaging Cohorts
Contributors
- Trinh, Matthew Brian (Author)
- Wang, Yalin (Thesis advisor)
- Liang, Jianming (Committee member)
- Su, Yi (Committee member)
- Arizona State University (Publisher)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2022
Subjects
Resource Type
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Note
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Partial requirement for: M.S., Arizona State University, 2022
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Field of study: Computer Science