Full metadata
Title
Unveiling Conceptual Shifts and Novel Dynamics in Genetic Engineering Science: A Gene Drive Case Study
Description
How is knowledge created at the intersections between basic science, biotechnology, and industry? Gene drives are an interesting example, as they combine a long-standing interest with a recent technological breakthrough and a new set of commercial applications. Gene drives are genes engineered such that they are preferentially inherited at a frequency greater than the typical Mendelian fifty percent ratio. During the historical and conceptual evolution of gene drives beginning in the 1960s, there have been many innovations and publications. Along with that, gene drive science developed considerable public attention, explosion of new scientists, and variation in the way the topic is discussed. It is now time to look at this new organization of science using a systematic approach to characterize the system that has enabled knowledge to grow in this scientific field. This project breaks new ground in how knowledge advances in genetic engineering science, and how scientists understand what a “gene drive” is through analysis of language, communities, and other social factors. In effect, this research will advance multiple fields and enable a deeper understanding of knowledge and complexity. This project documents patterns of publication, collaborative relationships, linguistic variation, innovation, and knowledge expansion. The results of computational analysis provide an in-depth and complete characterization of the structure, dynamics, and evolution of scientific knowledge found in the gene drive technology. Further, time series analysis of the multiple layers of discourse enabled a diachronic connective mapping of collaborative relationships and tracked linguistic variation and change, highlighting where ambiguous language may appear, improving and creating more cohesive scientific language.
Overall, depicting the structure, dynamics, and evolution of scientific knowledge during a novel eruption of scientific complexity can shed light on the factors that can lead to: (1) improved scientific communication, (2) reduction of scientific progress, (3) new knowledge, and (4) novel collaborative relationships. Therefore, characterizing the current technological, methodological, and social contexts that can influence scientific knowledge.
Date Created
2021
Contributors
- OToole, Cody Lane (Author)
- Laubichler, Manfred (Thesis advisor)
- Collins, James P (Committee member)
- Simeone, Michael (Committee member)
- Evans, James (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
279 pages
Language
eng
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.2.N.168385
Level of coding
minimal
Cataloging Standards
Note
Partial requirement for: Ph.D., Arizona State University, 2021
Field of study: Biology
System Created
- 2022-08-22 02:53:02
System Modified
- 2022-08-22 02:53:25
- 2 years 2 months ago
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