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Bdellovibrio bacteriovorus (BB) is a gram negative predatory bacteria that uses other gram negative bacteria to proliferate non-binarily. Due to the predatory nature of BB researchers have proposed to use it as a potential biocontrol agent against other gram negative bacteria. The in vivo effect of predatory bacteria on a living host lacks thorough investigation. This paper explores BB inside and outside of the C. elegans. BB acts internally by pre- infecting C. elegans with E. coli and then treating the worms with BB. After BB treatment worm survivavbility increased and morbidity decreased. Ex- ternally, BB modulated the environment around the nematode which reduced infection rates and increased nematode lifespan and survivability. Together, the internal and external results suggest BB has the capability to act as a living antibiotic acting topically and internally to reduce infection rates.
- Stambolic, Milena (Author)
- Presse, Steve (Thesis director)
- Vlcek, Jessi (Committee member)
- Barrett, The Honors College (Contributor)
- Department of Physics (Contributor)
- School of Mathematical and Statistical Sciences (Contributor)
- 2022-05-06 06:03:42
- 2023-01-10 11:47:14
- 1 year 10 months ago