Full metadata
Title
Pathway Analysis Reveals Sex Differences in Human Hepatocellular Carcinoma
Description
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and exhibits a male-bias in occurrence and mortality. Previous studies have provided insight into the role of inherited genetic regulation of transcription in modulating sex-differences in HCC etiology and mortality. This study uses pathway analysis to add insight into the biological processes that drive sex-differences in HCC etiology as well as a provide additional framework for future studies on sex-biased cancers. Gene expression data from normal, tumor adjacent, and HCC liver tissue were used to calculate pathway scores using a tool called PathOlogist that not only takes into consideration the molecules in a biological pathway, but also the interaction type and directionality of the signaling pathways. Analysis of the pathway scores uncovered etiologically relevant pathways differentiating male and female HCC. In normal and tumor adjacent liver tissue, males showed higher activity of pathways related to translation factors and signaling. Females did not show higher activity of any pathways compared to males in normal and tumor adjacent liver tissue. Work suggest biologic processes that underlie sex-biases in HCC occurrence and mortality. Both males and females differed in the activation of pathways related apoptosis, cell cycle, signaling, and metabolism in HCC. These results identify clinically relevant pathways for future research and therapeutic targeting.
Date Created
2021
Contributors
- Rehling, Thomas E (Author)
- Buetow, Kenneth (Thesis advisor)
- Wilson, Melissa (Committee member)
- Maley, Carlo (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
42 pages
Language
eng
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.2.N.161529
Level of coding
minimal
Cataloging Standards
Note
Partial requirement for: M.S., Arizona State University, 2021
Field of study: Molecular and Cellular Biology
System Created
- 2021-11-16 01:51:53
System Modified
- 2021-11-30 12:51:28
- 2 years 11 months ago
Additional Formats