The Characterization of Cannabidiol Amorphous Solid Dispersions

Generating amorphous solid dispersions (ASDs) containing active pharmaceutical ingredients has become a favorable technique of emerging prominence to improve drug solubility and overall bioavailability. Cannabidiol (CBD) has now become a major focus in cannabinoid research due to its ability to serve as an anti-inflammatory agent, showing promising results in treating a wide array of debilitating diseases and pathologies. The following work provides evidence for generating homogenous glass phase amorphous solid dispersions containing 50% (w/w) up to 75% (w/w) CBD concentrations in the domain size of 2 – 5 nm. Concentrations up to 85% (w/w) CBD were concluded homogenous in the supercooled liquid phase in domain sizes of 20 – 30 nm. The results were obtained from polarized light microscopy (PLM), differential scanning calorimetry (DSC), as well as solution and solid-state NMR spectroscopy.