Full metadata
Title
Engineering Cellular Transport Systems to Enhance Lignocellulose Bioconversion
Description
Lignocellulosic biomass represents a renewable domestic feedstock that can support large-scale biochemical production processes for fuels and specialty chemicals. However, cost-effective conversion of lignocellulosic sugars into valuable chemicals by microorganisms still remains a challenge. Biomass recalcitrance to saccharification, microbial substrate utilization, bioproduct titer toxicity, and toxic chemicals associated with chemical pretreatments are at the center of the bottlenecks limiting further commercialization of lignocellulose conversion. Genetic and metabolic engineering has allowed researchers to manipulate microorganisms to overcome some of these challenges, but new innovative approaches are needed to make the process more commercially viable. Transport proteins represent an underexplored target in genetic engineering that can potentially help to control the input of lignocellulosic substrate and output of products/toxins in microbial biocatalysts. In this work, I characterize and explore the use of transport systems to increase substrate utilization, conserve energy, increase tolerance, and enhance biocatalyst performance.
Date Created
2018
Contributors
- Kurgan, Gavin (Author)
- Wang, Xuan (Thesis advisor)
- Nielsen, David (Committee member)
- Misra, Rajeev (Committee member)
- Nannenga, Brent (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
205 pages
Language
eng
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.I.50438
Level of coding
minimal
Note
Doctoral Dissertation Biological Design 2018
System Created
- 2018-10-01 08:00:29
System Modified
- 2021-08-26 09:47:01
- 3 years 2 months ago
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