Full metadata
Title
The function of tyramine in the mouse uterine horn
Description
Pregnancy and childbirth are both natural occurring events, but still little is known about the signaling mechanisms that induce contractions. Throughout the world, premature labor occurs in 12% of all pregnancies with 36% of infant deaths resulting from preterm related causes. Even though the cause of preterm labor can vary, understanding alternative signaling pathways, which affect muscle contraction, could provide additional treatment options in stopping premature labor. The uterus is composed of smooth muscle, which is innervated, with a plexus of nerves that cover the muscle fibers. Smooth muscle can be stimulated or modulated by many sources such as neurotransmitters [i.e. dopamine], hormones [i.e. estrogen], peptides [i.e. oxytocin] and amines. This study focuses on the biogenic monoamine tyramine, which is produced in the tyrosine catecholamine biosynthesis pathway. Tyramine is known to be associated with peripheral vasoconstriction, increased cardiac output, increased respiration, elevated blood glucose and the release of norepinephrine. This research has found tyramine, and its specific receptor TAAR1, to be localized within mouse uterus and that this monoamine can induce uterine contractions at levels similar to oxytocin.
Date Created
2017
Contributors
- Obayomi, SM Bukola (Author)
- Baluch, Debra P (Thesis advisor)
- Deviche, Pierre (Thesis advisor)
- Smith, Brian H. (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
viii, 65 pages : color illustrations
Language
eng
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.I.43970
Statement of Responsibility
by SM Bukola Obayomi
Description Source
Retrieved on Aug. 29, 2017
Level of coding
full
Note
thesis
Partial requirement for: M.S., Arizona State University, 2017
bibliography
Includes bibliographical references (pages 58-63)
Field of study: Biology
System Created
- 2017-06-01 01:04:23
System Modified
- 2021-08-26 09:47:01
- 3 years 2 months ago
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