Full metadata
Title
Nanofluidics for single molecule DNA sequencing
Description
After a decade of efforts, accurate and affordable DNA sequencing continues to remain an important goal in current research landscape. This thesis starts with a brief overview of the recent updates in the field of DNA sequencing technologies followed by description of the nanofluidics route to single molecule DNA detection. Chapter 2 presents discusses carbon nanotube(CNT) based nanofluidics. The fabrication and DNA sensing measurements of CNT forest membrane devices are presented. Chapter 3 gives the background for functionalization and recognition aspects of reader molecules. Chapter 4 marks the transition to solid state nanopore nanofluidics. The fabrication of Imidazole functionalized nanopores is discussed. The Single Molecule detection results of DNA from Palladium nanopore devices are presented next. Combining chemical recognition to nanopore technology, it has been possible to prolong the duration of single molecule events from the order of a few micro seconds to upto a few milliseconds. Overall, the work presented in this thesis promises longer single molecule detection time in a nanofludic set up and paves way for novel nanopore- tunnel junction devices that combine recognition chemistry, tunneling device and nanopore approach.
Date Created
2013
Contributors
- Krishnakumar, Padmini (Author)
- Lindsay, Stuart (Thesis advisor)
- He, Jin (Committee member)
- Vaiana, Sara (Committee member)
- Schmidt, Kevin (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
xi, 131 p. : ill. (some col.)
Language
eng
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.I.18764
Statement of Responsibility
by Padmini Krishnakumar
Description Source
Retrieved on Jan. 28, 2014
Level of coding
full
Note
thesis
Partial requirement for: Ph.D., Arizona State University, 2013
bibliography
Includes bibliographical references (p. 110-112)
Field of study: Physics
System Created
- 2013-10-08 04:24:21
System Modified
- 2021-08-30 01:38:16
- 3 years 2 months ago
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