Full metadata
Title
Synthesis of multifunctional radical quenchers (MRQ's)
Description
Mitochondria produce most of the ATP needed for the cell as an energy source. It is well known that cellular respiration results in oxidative damage to the cell due to the production of reactive oxygen species (ROS). Mitochondrial dysfunction is believed to contribute to a number of degenerative diseases; because of this the mitochondrial respiratory chain is considered as potential drug target. A few series of idebenone analogues with quinone, pyridinol and pyrimidinol redox cores have been synthesized and evaluated as antioxidants able to protect cellular integrity and, more specifically, mitochondrial function. The compounds exhibited a range of activities. The activities observed were used for the design of analogues with enhanced properties as antioxidants. Compounds were identified which provide better protection against oxidative stress than idebenone, and it is thought that they do so catalytically.
Date Created
2012
Contributors
- Arce Amezquita, Pablo M (Author)
- Hecht, Sidney M. (Thesis advisor)
- Moore, Ana (Committee member)
- Rose, Seth (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
xv, 192 p. : ill. (some col.)
Language
eng
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.I.15932
Statement of Responsibility
by Pablo M. Arce Amezquita
Description Source
Retrieved on Oct. 1, 2013
Level of coding
full
Note
thesis
Partial requirement for: Ph.D., Arizona State University, 2012
bibliography
Includes bibliographical references (p. 183-190)
Field of study: Chemistry
System Created
- 2013-01-17 06:39:05
System Modified
- 2021-08-30 01:44:00
- 3 years ago
Additional Formats