Description
CpG methylation is an essential requirement for the normal development of mammals, but aberrant changes in the methylation can lead to tumor progression and cancer. An in-depth understanding of this phenomenon can provide insights into the mechanism of gene repression. We present a study comparing methylated DNA and normal DNA wrt its persistence length and contour length. Although, previous experiments and studies show no difference between the physical properties of the two, the data collected and interpreted here gives a different picture to the methylation phenomena and its effect on gene silencing. The study was extended to the artificially reconstituted chromatin and its interactions with the methyl CpG binding proteins were also probed.
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Details
Title
- AFM study of gene silencing by DNA methylation and its interactions involving chromatin and methyl CpG binding proteins
Contributors
- Kaur, Parminder (Author)
- Lindsay, Stuart (Thesis advisor)
- Ros, Robert (Committee member)
- Tao, Nongjian (Committee member)
- Vaiana, Sara (Committee member)
- Beckenstein, Oliver (Committee member)
- Arizona State University (Publisher)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2012
Resource Type
Collections this item is in
Note
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thesisPartial requirement for: Ph.D., Arizona State University, 2012
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bibliographyIncludes bibliographical references
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Field of study: Physics
Citation and reuse
Statement of Responsibility
by Parminder Kaur