Full metadata
Title
Identification of Tumor Associated Antigens using Nucleic Acid Programmable Protein Arrays
Description
Identifying disease biomarkers may aid in the early detection of breast cancer and improve patient outcomes. Recent evidence suggests that tumors are immunogenic and therefore patients may launch an autoantibody response to tumor associated antigens. Single-chain variable fragments of autoantibodies derived from regional lymph node B cells of breast cancer patients were used to discover these tumor associated biomarkers on protein microarrays. Six candidate biomarkers were discovered from 22 heavy chain-only variable region antibody fragments screened. Validation tests are necessary to confirm the tumorgenicity of these antigens. However, the use of single-chain variable autoantibody fragments presents a novel platform for diagnostics and cancer therapeutics.
Date Created
2012-12
Contributors
- Sharman, M. Camila (Author)
- Magee, Dewey (Mitch) (Thesis director)
- Wallstrom, Garrick (Committee member)
- Petritis, Brianne (Committee member)
- Barrett, The Honors College (Contributor)
- College of Liberal Arts and Sciences (Contributor)
- Virginia G. Piper Center for Personalized Diagnostics (Contributor)
- Biodesign Institute (Contributor)
Topical Subject
Resource Type
Extent
37 pages
Language
eng
Copyright Statement
In Copyright
Primary Member of
Series
Academic Year 2012-2013
Handle
https://hdl.handle.net/2286/R.I.15775
Level of coding
minimal
Cataloging Standards
System Created
- 2017-10-30 02:50:57
System Modified
- 2021-08-11 04:09:57
- 3 years 3 months ago
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