Description
Misfolding and aggregation of alpha-synuclein (a-syn) has been strongly correlated with the pathogenesis of Parkinson's disease (PD). Reagents such as single chain antibody fragments (scFv) that can interact with specific aggregate forms of a-syn can be very useful to study how different aggregate forms affect cells. Here we utilize two scFvs, D5 and 10H, that recognize two distinct oligomeric forms of a-syn to characterize the presence of different a-syn aggregates in animal models of PD.
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Title
- Detecting Oligomeric Forms of Alpha-Synuclein in Cell and Mouse Tissue
Contributors
- Alam, Now Bahar (Author)
- Sierks, Michael (Thesis director)
- Pauken, Christine (Committee member)
- Williams, Stephanie (Committee member)
- Barrett, The Honors College (Contributor)
- Department of Psychology (Contributor)
- Harrington Bioengineering Program (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2013-05
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