Full metadata
Title
Discovering factors that drive the migration of immune cells to malignant pleural mesothelioma tumors
Description
Malignant Pleural Mesothelioma (MPM) is an aggressive deadly tumor that has few therapeutic options. Immunotherapies have shown great potential in alleviating MPM patient symptoms. Using patient data from the Cancer Genome Atlas (TCGA) we sought to identify mutations, regulators, and immune factors driving immune cell migration. We explored computational methods to define regulatory causal flows in order to make biological predictions. These predictions were verified by cross-referencing peer-reviewed articles. A disease-relevant inference model was developed to examine the chemokine IL-18’s effect on natural killer cell (NK cell) migration.
Date Created
2020-05
Contributors
- Wipper, Gabrielle Frances (Author)
- Plaisier, Christopher (Thesis director)
- Plaisier, Seema (Committee member)
- Harrington Bioengineering Program (Contributor, Contributor)
- Barrett, The Honors College (Contributor)
Topical Subject
Resource Type
Extent
21 pages
Language
eng
Copyright Statement
In Copyright
Primary Member of
Series
Academic Year 2019-2020
Handle
https://hdl.handle.net/2286/R.I.56219
Level of coding
minimal
Cataloging Standards
System Created
- 2020-04-14 12:00:11
System Modified
- 2021-08-11 04:09:57
- 3 years 1 month ago
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