Description
Although extracellular throughout their lifecycle, trypanosomes are able to persist despite strong host immune responses through a process known as antigenic variation involving a large, highly diverse family of surface glycopro- tein (VSG) genes, only one of which is expressed at a time. Previous studies have used mathematical models to investigate the relationship between VSG switching and the dynamics of trypanosome infections, but none have explored the role of multiple VSG expression sites or the contribution of mosaic gene conversion events involving VSG pseudogenes.
Details
Title
- The Role of Multiple Expression Sites and Mosaic Gene Conversion in Antigenic Variation in African Trypanosomes
Contributors
- Koury, Michael Andrew (Author)
- Taylor, Jesse (Thesis director)
- Gumel, Abba (Committee member)
- Department of Physics (Contributor)
- School of Mathematical and Statistical Sciences (Contributor)
- Barrett, The Honors College (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2020-05
Resource Type
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