Full metadata
Title
Sequence Diversity of Pan troglodytes Subspecies and the Impact of WFDC6 Selective Constraints in Reproductive Immunity
Description
Recent efforts have attempted to describe the population structure of common chimpanzee, focusing on four subspecies: Pan troglodytes verus, P. t. ellioti, P. t. troglodytes, and P. t. schweinfurthii. However, few studies have pursued the effects of natural selection in shaping their response to pathogens and reproduction. Whey acidic protein (WAP) four-disulfide core domain (WFDC) genes and neighboring semenogelin (SEMG) genes encode proteins with combined roles in immunity and fertility. They display a strikingly high rate of amino acid replacement (dN/dS), indicative of adaptive pressures during primate evolution. In human populations, three signals of selection at the WFDC locus were described, possibly influencing the proteolytic profile and antimicrobial activities of the male reproductive tract. To evaluate the patterns of genomic variation and selection at the WFDC locus in chimpanzees, we sequenced 17 WFDC genes and 47 autosomal pseudogenes in 68 chimpanzees (15 P. t. troglodytes, 22 P. t. verus, and 31 P. t. ellioti). We found a clear differentiation of P. t. verus and estimated the divergence of P. t. troglodytes and P. t. ellioti subspecies in 0.173 Myr; further, at the WFDC locus we identified a signature of strong selective constraints common to the three subspecies in WFDC6—a recent paralog of the epididymal protease inhibitor EPPIN. Overall, chimpanzees and humans do not display similar footprints of selection across the WFDC locus, possibly due to different selective pressures between the two species related to immune response and reproductive biology.
Date Created
2013-12-19
Contributors
- Ferreira, Zelia (Author)
- Hurle, Belen (Author)
- Andres, Aida M. (Author)
- Kretzschmar, Warren W. (Author)
- Mullikin, James C. (Author)
- Cherukuri, Praveen F. (Author)
- Cruz, Pedro (Author)
- Gonder, Mary Katherine (Author)
- Stone, Anne (Author)
- Tishkoff, Sarah (Author)
- Swanson, Willie J. (Author)
- Green, Eric D. (Author)
- Clark, Andrew G. (Author)
- Seixas, Susana (Author)
- NISC Comparative Sequencing Program (Author)
- College of Liberal Arts and Sciences (Contributor)
- School of Human Evolution and Social Change (Contributor)
- School of Life Sciences (Contributor)
Resource Type
Extent
12 pages
Language
eng
Copyright Statement
No Copyright - United States
Primary Member of
Identifier
Digital object identifier: 10.1093/gbe/evt198
Identifier Type
International standard serial number
Identifier Value
1759-6653
Series
GENOME BIOLOGY AND EVOLUTION
Handle
https://hdl.handle.net/2286/R.I.45407
Preferred Citation
Ferreira, Z., Hurle, B., Andrés, A. M., Kretzschmar, W. W., Mullikin, J. C., Cherukuri, P. F., . . . Seixas, S. (2013). Sequence Diversity of Pan troglodytes Subspecies and the Impact of WFDC6 Selective Constraints in Reproductive Immunity. Genome Biology and Evolution, 5(12), 2512-2523. doi:10.1093/gbe/evt198
Level of coding
minimal
Cataloging Standards
Note
The final version of this article, as published in Genome Biology and Evolution, can be viewed online at: https://academic.oup.com/gbe/article-lookup/doi/10.1093/gbe/evt198
System Created
- 2017-09-13 02:51:40
System Modified
- 2021-08-16 02:23:30
- 3 years 3 months ago
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