Description

It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported

It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

Reuse Permissions
  • Details

    Title
    • A Recent Bottleneck of Y Chromosome Diversity Coincides With a Global Change in Culture
    Contributors
    Agent
    Date Created
    2015-04-01
    Collections this item is in
    Identifier
    • Digital object identifier: 10.1101/gr.186684.114
    • Identifier Type
      International standard serial number
      Identifier Value
      1088-9051
    • Identifier Type
      International standard serial number
      Identifier Value
      1549-5469

    Citation and reuse

    Cite this item

    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Karmin, Monika; Saag, Lauri; Vicente, Mario; et.al. (2015). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. GENOME RESEARCH, 25(4), 459-466. http://dx.doi.org/10.1101/gr.186684.114

    Machine-readable links