It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
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- A Recent Bottleneck of Y Chromosome Diversity Coincides With a Global Change in Culture
- Karmin, Monika (Author)
- Saag, Lauri (Author)
- Vicente, Mario (Author)
- Wilson Sayres, Melissa (Author)
- Jarve, Mari (Author)
- Talas, Ulvi Gerst (Author)
- Rootsi, Siiri (Author)
- Ilumaee, Anne-Mai (Author)
- Maegi, Reedik (Author)
- Mitt, Mario (Author)
- Pagani, Luca (Author)
- Puurand, Tarmo (Author)
- Faltyskova, Zuzana (Author)
- Clemente, Florian (Author)
- Cardona, Alexia (Author)
- Metspalu, Ene (Author)
- Sahakyan, Hovhannes (Author)
- Yunusbayev, Bayazit (Author)
- Hudjashov, Georgi (Author)
- DeGiorgio, Michael (Author)
- Loogvaeli, Eva-Liis (Author)
- Eichstaedt, Christina (Author)
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- Hammer, Michael F. (Author)
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- Johnsen, Knut (Author)
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Digital object identifier: 10.1101/gr.186684.114
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Identifier TypeInternational standard serial numberIdentifier Value1088-9051
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Identifier TypeInternational standard serial numberIdentifier Value1549-5469
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Karmin, Monika; Saag, Lauri; Vicente, Mario; et.al. (2015). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. GENOME RESEARCH, 25(4), 459-466. http://dx.doi.org/10.1101/gr.186684.114