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The use of botanical medicine by practitioners and the general public has dramatically increased in recent years. Most of these botanical therapeutics are obtained through commercial manufacturers or nutraceutical companies. The current standard of practice that manufacturers typically use to

The use of botanical medicine by practitioners and the general public has dramatically increased in recent years. Most of these botanical therapeutics are obtained through commercial manufacturers or nutraceutical companies. The current standard of practice that manufacturers typically use to standardize botanicals is done based on the level of a well-known, abundant marker compound present in the botanical. This study evaluated the putative correlation between the level of a marker compound and the biological activity of eight common botanicals. Overall, the standardization of a botanical based on a marker compound was found not to be a reliable method when compared to in vitro bioactivity. A marker compound is often not the biologically active component of a plant and therefore the level of such a marker compound does not necessarily correlate with biological activity or therapeutic efficacy.

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    Title
    • A Lack of Bioactive Predictability for Marker Compounds Commonly Used for Herbal Medicine Standardization
    Date Created
    2016-07-26
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0159857
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560
    Note
    • The article is published at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159857

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    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Ruiz, G. G., Nelson, E. O., Kozin, A. F., Turner, T. C., Waters, R. F., & Langland, J. O. (2016). A Lack of Bioactive Predictability for Marker Compounds Commonly Used for Herbal Medicine Standardization. Plos One, 11(7). doi:10.1371/journal.pone.0159857

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