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The increasing world demand for human biologics cannot be met by current production platforms based primarily on mammalian cell culture due to prohibitive cost and limited scalability [1]. Recent progress in plant expression vector development, downstream processing, and glycoengineering has

The increasing world demand for human biologics cannot be met by current production platforms based primarily on mammalian cell culture due to prohibitive cost and limited scalability [1]. Recent progress in plant expression vector development, downstream processing, and glycoengineering has established plants as a superior alternative to biologic production [2–4]. Plants not only offer the traditional advantages of proper eukaryotic protein modification, potential low cost, high scalability, and increased safety but also allow the production of biologics at unprecedented speed to control potential pandemics or with specific glycoforms for better efficacy or safety (biobetters) [5, 6]. The approval of the first plant-made biologic (PMB) by the United States Food and Drug Administration (FDA) for treating Gaucher’s disease heralds a new era for PMBs and sparks new innovations in this field [7, 8].

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    Title
    • Plant-Made Biologics
    Contributors
    Date Created
    2014-06-02
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1155/2014/418064
    • Identifier Type
      International standard serial number
      Identifier Value
      2314-6133
    • Identifier Type
      International standard serial number
      Identifier Value
      2314-6141
    Note
    • View the article as published at https://www.hindawi.com/journals/bmri/2014/418064/

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    Chen, Q., Santi, L., & Zhang, C. (2014). Plant-Made Biologics. BioMed Research International, 2014, 1-3. doi:10.1155/2014/418064

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