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Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to disease, including infectious diseases. To evaluate the potential impact of the spaceflight environment on the regulation

Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to disease, including infectious diseases. To evaluate the potential impact of the spaceflight environment on the regulation of molecular pathways mediating cellular stress responses, we performed a first-of-its-kind pilot study to assess spaceflight-related gene-expression changes in the whole blood of astronauts. Using an array comprised of 234 well-characterized stress-response genes, we profiled transcriptomic changes in six astronauts (four men and two women) from blood preserved before and immediately following the spaceflight. Differentially regulated transcripts included those important for DNA repair, oxidative stress, and protein folding/degradation, including HSP90AB1, HSP27, GPX1, XRCC1, BAG-1, HHR23A, FAP48, and C-FOS. No gender-specific differences or relationship to number of missions flown was observed. This study provides a first assessment of transcriptomic changes occurring in the whole blood of astronauts in response to spaceflight.

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    Title
    • Spaceflight Modulates Gene Expression in the Whole Blood of Astronauts
    Date Created
    2016-12-08
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1038/npjmgrav.2016.39
    • Identifier Type
      International standard serial number
      Identifier Value
      2373-8065
    Note
    • The final version of this article, as published in Npj Microgravity, can be viewed online at: http://www.nature.com/articles/npjmgrav201639

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    Barrila, J., Ott, C. M., Leblanc, C., Mehta, S. K., Crabbé, A., Stafford, P., . . . Nickerson, C. A. (2016). Spaceflight modulates gene expression in the whole blood of astronauts. Npj Microgravity, 2(1). doi:10.1038/npjmgrav.2016.39

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